{"id":618,"date":"2024-04-28T09:48:06","date_gmt":"2024-04-28T06:48:06","guid":{"rendered":"https:\/\/odyova.com\/haberler\/?p=618"},"modified":"2024-04-28T09:48:06","modified_gmt":"2024-04-28T06:48:06","slug":"papilloma","status":"publish","type":"post","link":"https:\/\/odyova.com\/haberler\/papilloma\/","title":{"rendered":"Papilloma"},"content":{"rendered":"
LAR\u0130NGEAL PAP\u0130LLOMATOS\u0130S<\/strong><\/div>\n
HPV (Human Papilloma Virus) enfeksiyonunun ses teli epiteli \u00fczerinde yaratt\u0131\u011f\u0131 bir patolojidir. HPV' nin 100' e yak\u0131n tipi bulunmaktad\u0131r. Bu tipler aras\u0131nda 6, 11, 16, 18 numaral\u0131 tipler ses tellerini etkilemektedir. Hastal\u0131\u011f\u0131n malign (k\u00f6t\u00fc huylu) kitleler d\u00f6n\u00fc\u015fme ihtimali mevcuttur \u00f6zellikle 16 ve 18 tipleri baz\u0131 larinks kanser t\u00fcrlerinin nedenleri aras\u0131nda g\u00f6sterilmektedir. Bu nedenle takip ve tedavisi \u00f6nemlidir.<\/div>\n
\n

HPV (Human Papilloma Vir\u00fcs)<\/strong><\/p>\n

HPV DNA vir\u00fcs\u00fcd\u00fcr. Bu nedenle insan geneti\u011fine entegre olabilme \u00f6zelli\u011fi ta\u015f\u0131r. Viral DNA kanser h\u00fccre genomuna entegre olarak kanser s\u00fcrecini ba\u015flatabilmektedir. HPV' nin dokuda kal\u0131\u015f s\u00fcresi bu karsinojenik s\u00fcreci daha da kolayla\u015ftrmaktad\u0131r. Hastal\u0131\u011f\u0131n dokuda s\u00fcre\u011fenli\u011finin en \u00f6nemli sebebinin v\u00fccudun savunma mekanizmas\u0131n\u0131n verdi\u011fi yetersiz yan\u0131t oldu\u011fu d\u00fc\u015f\u00fcn\u00fclmektedir. \u00d6zellikle HPV tip 6 ve 11' lerle yap\u0131lan \u00e7al\u0131\u015fmalar v\u00fccudun bu tiplere kar\u015f\u0131 yetersiz ba\u011f\u0131\u015f\u0131kl\u0131k yan\u0131t\u0131 sonucunda olu\u015ftu\u011fu g\u00f6stermektedir. <\/span><\/p>\n

HPV DNA's\u0131 papilomatosis, verr\u00fck\u00f6z lezyonlar ve malign yass\u0131 h\u00fccreli t\u00fcm\u00f6rlerde saptanm\u0131\u015ft\u0131r. HPV tip 6 ve 11 d\u00fc\u015f\u00fck riskli vir\u00fcslerdir. Tip 16 ve 18 verr\u00fck\u00f6z ve malign yass\u0131 h\u00fccrelerde saptand\u0131\u011f\u0131 i\u00e7in riskli grubu olu\u015fturmaktad\u0131r. \u00c7al\u0131\u015fmalar g\u0131rtlak kanserlerinin % 25' lik b\u00f6l\u00fcm\u00fcn\u00fcn HPV ile ili\u015fkili oldu\u011funu g\u00f6stermektedir. Erken evre larinks t\u00fcm\u00f6rlerinin % 16' s\u0131n\u0131n HPV ile ili\u015fkili oldu\u011fu g\u00f6sterilmi\u015f ve farkl\u0131 tiplerde (26,31,39,52) HPV DNA' s\u0131 saptanm\u0131\u015ft\u0131r.<\/p>\n

B\u00f6lgesel olarak enfeksiyonun yaratt\u0131\u011f\u0131 kanser riski de de\u011fi\u015fmektedir. Tayvan' da insidans 2,5\/100 ki\u015fi\/y\u0131l saptanm\u0131\u015ft\u0131r. Ayr\u0131ca HPV DNA' s\u0131 saptanmayan olgularda riskin daha fazla oldu\u011fu; olu\u015fumda ya\u015f, alkol, sigara kullan\u0131m\u0131n\u0131n ili\u015fkili olmad\u0131\u011f\u0131 g\u00f6sterilmi\u015ftir. <\/p>\n<\/div>\n

\n

Pediatrik \/ \u00c7ocukluk \u00e7a\u011f\u0131 Papillomatozis<\/strong><\/p>\n

Pediatrik ya\u015f grubunda g\u00f6r\u00fclen papillomatosis larinks d\u0131\u015f\u0131nda trakea, bron\u015flar\u0131 da etkilemektedir. Havayolunu t\u0131kama riski y\u00fcksektir dolay\u0131s\u0131yla tedavisi de kapsaml\u0131 ve zordur. Pediatrik grupta HPV tip 6 ve 11 enfeksiyonu d\u0131\u015f\u0131nda 13,39,40,56 tipleri de e\u015flik edebilmektedir. <\/p>\n<\/div>\n

\n

TANI<\/strong><\/p>\n

Biyopsi, patolojik inceleme ve PCR (polimerase Chain Reaction) teknikleri ile konmaktad\u0131r<\/p>\n<\/div>\n

\n

TEDAV\u0130<\/strong><\/p>\n

– Basit eksizyon<\/p>\n

– Lazer vaporizasyon<\/p>\n

– Fotodinamik terapi<\/p>\n

– Antiviral tedavi: IFN alfa, intralezyoner Cidofovir enjeksiyonu <\/p>\n<\/div>\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

Papilloma Konu hakk\u0131nda detayl\u0131 ve g\u00fcncel bilgiler i\u00e7in bu makaleyi okuyun<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[18],"tags":[260,258,135,259],"class_list":["post-618","post","type-post","status-publish","format-standard","hentry","category-kulak-burun-bogaz","tag-dna","tag-hpv","tag-kanser","tag-tip"],"_links":{"self":[{"href":"https:\/\/odyova.com\/haberler\/wp-json\/wp\/v2\/posts\/618","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/odyova.com\/haberler\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/odyova.com\/haberler\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/odyova.com\/haberler\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/odyova.com\/haberler\/wp-json\/wp\/v2\/comments?post=618"}],"version-history":[{"count":1,"href":"https:\/\/odyova.com\/haberler\/wp-json\/wp\/v2\/posts\/618\/revisions"}],"predecessor-version":[{"id":619,"href":"https:\/\/odyova.com\/haberler\/wp-json\/wp\/v2\/posts\/618\/revisions\/619"}],"wp:attachment":[{"href":"https:\/\/odyova.com\/haberler\/wp-json\/wp\/v2\/media?parent=618"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/odyova.com\/haberler\/wp-json\/wp\/v2\/categories?post=618"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/odyova.com\/haberler\/wp-json\/wp\/v2\/tags?post=618"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}